Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation
AKT pathway has a critical role in mediating signaling transductions for cell proliferation,
differentiation and survival. Previous studies have shown that AKT activation is achieved …
differentiation and survival. Previous studies have shown that AKT activation is achieved …
A kinase-independent function of AKT promotes cancer cell survival
The serine–threonine kinase AKT regulates proliferation and survival by phosphorylating a
network of protein substrates. In this study, we describe a kinase-independent function of …
network of protein substrates. In this study, we describe a kinase-independent function of …
AKT signalling in the failing heart
AH Chaanine, RJ Hajjar - European journal of heart failure, 2011 - Wiley Online Library
AKT is a serine/threonine protein kinase, also known as protein kinase B, which regulates
cardiac growth, myocardial angiogenesis, glucose metabolism, and cell death in cardiac …
cardiac growth, myocardial angiogenesis, glucose metabolism, and cell death in cardiac …
Targeting AKT for cancer therapy
M Shariati, F Meric-Bernstam - Expert opinion on investigational …, 2019 - Taylor & Francis
Introduction: Targeted therapies in cancer aim to inhibit specific molecular targets
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
B Dummler, O Tschopp, D Hynx, ZZ Yang… - … and cellular biology, 2006 - Taylor & Francis
To address the issues of isoform redundancy and isoform specificity of the Akt family of
protein kinases in vivo, we generated mice deficient in both Akt2 and Akt3. In these mice …
protein kinases in vivo, we generated mice deficient in both Akt2 and Akt3. In these mice …
Akt activation in platelets depends on Gi signaling pathways
S Kim, J Jin, SP Kunapuli - Journal of Biological Chemistry, 2004 - ASBMB
The serine-threonine kinase Akt has been established as an important signaling
intermediate in regulating cell survival, cell cycle progression, as well as agonist-induced …
intermediate in regulating cell survival, cell cycle progression, as well as agonist-induced …
[PDF][PDF] AKT/PKB signaling mechanisms in cancer and chemoresistance
Background 3. Comparison of Akt isoforms 3.1. Sequence comparison and expression
pattern 3.2. Phenotype of the knock-out mouse 4. Akt oncogenic activity and its role in …
pattern 3.2. Phenotype of the knock-out mouse 4. Akt oncogenic activity and its role in …
AKT plays a central role in tumorigenesis
JR Testa, A Bellacosa - Proceedings of the National …, 2001 - National Acad Sciences
Mayo and Donner (1) report on yet another function of AKT, involving regulation of the
Mdm2p53 pathway. The first evidence pointing to a role of AKT in oncogenesis was …
Mdm2p53 pathway. The first evidence pointing to a role of AKT in oncogenesis was …
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
Akf proto-oncogene is catalytically inactive in serum-starved primary and immortalized
fibroblasts. Here we show that Akt and the Akt-related kinase AKT2 are activated by PDGF …
fibroblasts. Here we show that Akt and the Akt-related kinase AKT2 are activated by PDGF …