Objective The results of recent animal studies suggest that activation of Wnt/β‐catenin
signaling in articular chondrocytes might be a driving factor in the pathogenesis of …

A fine balance between anabolic and catabolic mechanisms maintains extracellular matrix
homeostasis in articular cartilage, and shifts toward degradation are associated with joint …

Objective Osteoarthritis is a degenerative joint disease whose molecular mechanism is
currently unknown. Wnt/β‐catenin signaling has been demonstrated to play a critical role in …

Introduction In this study, we tested the ability of small molecule inhibitors of WNT/β-catenin
signaling to block interleukin 1β (IL-1β)-and tumor necrosis factor α (TNFα)-induced …

Objective Wnt signaling is a master regulator of joint homeostasis, but its role in
osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation …

Objective To determine the possible involvement and regulatory mechanisms of Wnt‐5A
signaling in interleukin‐1β (IL‐1β)–induced increase in matrix metalloproteinase 1 (MMP‐1) …

Summary Objective Aberrant Wnt signaling may contribute to osteoarthritis (OA) but the Wnt
family members involved have not been fully identified. The purpose of this study was to …

Abstract Purpose of Review Arthritis defines a large group of diseases primarily affecting the
joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the …

Recent evidence from animal experiments and clinical samples points at a role for Wnt-
signaling in osteoarthritis (OA) pathology. These pathways are key inducers and regulators …

Interleukin (IL)-1β is a major catabolic cytokine that plays a pivotal role in cartilage
destruction. This study examined the possible involvement and regulatory mechanisms of …