DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors
Y Liu, R Kuick, S Hanash, B Richardson - Clinical immunology, 2009 - Elsevier
Killer-cell immunoglobulin-like receptor (KIR) genes are a polymorphic family expressed on
NK cells, and “senescent” CD28− T cells implicated in cardiovascular disease. KIR …
NK cells, and “senescent” CD28− T cells implicated in cardiovascular disease. KIR …
Epigenetic regulation of killer immunoglobulin–like receptor expression in T cells
G Li, M Yu, CM Weyand… - Blood, The Journal of the …, 2009 - ashpublications.org
With increasing age, T cells gain expression of killer immunoglobulin–like receptors (KIRs)
that transmit negative signals and dampen the immune response. KIR expression is induced …
that transmit negative signals and dampen the immune response. KIR expression is induced …
Ascorbic acid promotes KIR demethylation during early NK cell differentiation
Variegated expression of killer Ig-like receptors (KIR) in human NK cells is a stochastic
process exclusive to subsets of mature NK cells and CD8+ T cells. Allele-specific KIR …
process exclusive to subsets of mature NK cells and CD8+ T cells. Allele-specific KIR …
[HTML][HTML] DNA methylation maintains allele-specific KIR gene expression in human natural killer cells
HW Chan, ZB Kurago, CA Stewart… - The Journal of …, 2003 - ncbi.nlm.nih.gov
Killer immunoglobulin-like receptors (KIR) bind self–major histocompatibility complex class I
molecules, allowing natural killer (NK) cells to recognize aberrant cells that have down …
molecules, allowing natural killer (NK) cells to recognize aberrant cells that have down …
Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells
G Li, CM Weyand, JJ Goronzy - Journal of Leucocyte Biology, 2008 - academic.oup.com
Killer Ig-like receptor (KIR) expression is mostly restricted to NK cells controlling their
activation. With increasing age, KIRs are expressed on T cells and contribute to age-related …
activation. With increasing age, KIRs are expressed on T cells and contribute to age-related …
Demethylating treatment suppresses natural killer cell cytolytic activity
X Gao, J Lin, L Wang, L Yu - Molecular immunology, 2009 - Elsevier
NK cells as a component of the innate immune system provide a first line of defense against
viral infections and malignancies. Killer immunoglobulin-like receptors (KIRs) are a …
viral infections and malignancies. Killer immunoglobulin-like receptors (KIRs) are a …
Epigenetic control of highly homologous killer Ig-like receptor gene alleles
HW Chan, JS Miller, MB Moore… - The Journal of Immunology, 2005 - journals.aai.org
Mature human NK lymphocytes express the highly homologous killer Ig-like receptor (KIR)
genes in a stochastic fashion, and KIR transcription precisely correlates with allele-specific …
genes in a stochastic fashion, and KIR transcription precisely correlates with allele-specific …
Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells
S Santourlidis, HI Trompeter, S Weinhold… - The journal of …, 2002 - journals.aai.org
Human NK cells are characterized by the expression of surface receptors of the killer cell Ig-
like receptor (KIR) family, which are involved in the specific recognition of pathogenic target …
like receptor (KIR) family, which are involved in the specific recognition of pathogenic target …
Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of …
HI Trompeter, N Gómez-Lozano… - The Journal of …, 2005 - journals.aai.org
The generation of killer cell Ig-like receptor (KIR) expression patterns in NK cells involves
variegated silencing of KIR genes by DNA methylation. To identify regulatory elements …
variegated silencing of KIR genes by DNA methylation. To identify regulatory elements …
Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells
D Basu, Y Liu, A Wu, S Yarlagadda… - The Journal of …, 2009 - journals.aai.org
T cells from lupus patients have hypomethylated DNA and overexpress genes normally
suppressed by DNA methylation that contribute to disease pathogenesis. We found that …
suppressed by DNA methylation that contribute to disease pathogenesis. We found that …