Cilostazol induces apoptosis and inhibits proliferation of hepatocellular carcinoma cells by activating AMPK

KH Sim, MS Shu, S Kim, JY Kim, BH Choi… - Biotechnology and …, 2021 - Springer
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the
leading causes of cancer-related death. Cilostazol, an antiplatelet drug, elicits anticancer …

[HTML][HTML] Cilostazol protects hepatocytes against alcohol-induced apoptosis via activation of AMPK pathway

YJ Lee, MS Shu, JY Kim, YH Kim, KH Sim, WJ Sung… - PLoS …, 2019 - journals.plos.org
Alcoholic liver disease (ALD) is a worldwide health problem and hepatocyte apoptosis has
been associated with the development/progression of ALD. However, no definite effective …

[HTML][HTML] Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2

Q Yin, F Yan, XY Zu, Y Wu, X Wu, M Liao, S Deng… - Cytotechnology, 2012 - Springer
Carvacrol is one of the members of monoterpene phenol and is present in the volatile oils of
Thymus vulgaris, Carum copticum, origanum and oregano. It is a safe food additive …

Cilostazol reduces proliferation through c-Myc down-regulation in MDCK cells

B Muñoz, M Huerta, E López-Bayghen - European journal of pharmacology, 2009 - Elsevier
Cilostazol, a drug commonly used in the treatment of intermittent claudication is a selective
phosphodiesterase III inhibitor. It affects cell proliferation, increases cAMP levels, activates …

Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells

K Fan, X Li, Y Cao, H Qi, L Li, Q Zhang, H Sun - Anti-cancer drugs, 2015 - journals.lww.com
Colon cancer is one of the most common malignancies worldwide and has a high mortality
rate. Carvacrol is a major component of oregano and thyme essential oils and shows …

[HTML][HTML] Ciclopirox olamine induces proliferation inhibition and protective autophagy in hepatocellular carcinoma

X Wan, J Xiang, H Fan, Y Jiang, Y Lu, C Zhang… - Pharmaceuticals, 2023 - mdpi.com
Hepatocellular carcinoma is one of the most common fatal malignancies worldwide. Thus
far, the hepatocellular carcinoma prognosis has been bleak due to deficiencies in the …

[HTML][HTML] The HDAC inhibitor quisinostat (JNJ-26481585) supresses hepatocellular carcinoma alone and synergistically in combination with sorafenib by G0/G1 phase …

B He, L Dai, X Zhang, D Chen, J Wu… - … journal of biological …, 2018 - ncbi.nlm.nih.gov
The high activity of Histone deacetylases (HDACs) in hepatocellular carcinoma (HCC)
usually positively correlates with poor prognosis of patients. Accordingly histone …

Zolmitriptan attenuates hepatocellular carcinoma via activation of caspase mediated apoptosis

V Maurya, P Kumar, S Chakraborti, AK Singh… - Chemico-biological …, 2019 - Elsevier
A preclinical study using DEN-induced HCC rat model was attempted to evaluate the
antitumor potential of zolmitriptan (ZOL). The molecular insights were investigated using …

The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis

J Okano, T Nagahara, K Matsumoto… - Oncology …, 2007 - spandidos-publications.com
Paclitaxel is a chemotherapeutic drug applied for the treatment of breast and non-small cell
lung cancers. However, the biological effects of paclitaxel on hepatocellular carcinoma …

[HTML][HTML] Niclosamide inhibits cell growth and enhances drug sensitivity of hepatocellular carcinoma cells via STAT3 signaling pathway

C Wang, X Zhou, H Xu, X Shi, J Zhao, M Yang… - Journal of …, 2018 - ncbi.nlm.nih.gov
Aims: Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor
worldwide, with a high mortality rate at advanced stages. In this study, we investigated the …