The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …

The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …

Abstract The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …

The accessory Nef protein of HIV and SIV is essential for viral pathogenesis, yet it is
perplexing in its multitude of molecular functions. In this review we analyse the structure …

The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …

The human immunodeficiency virus 1 (HIV‐1) Nef protein is a pathogenicity factor required
for effective progression to AIDS, which modulates host cell signaling pathways and T‐cell …

Nef, a human immunodeficiency virus type 1 (HIV-1) accessory factor capable of interaction
with a diverse array of host cell signaling molecules, is essential for high-titer HIV replication …

The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote
viral pathogenesis and is an attractive target for the development of novel therapeutics. A …

The Nef protein of the type 1 human immunodeficiency virus (HIV-1) plays a key although
poorly understood role in accelerating the progression of clinical disease in vivo. Nef exerts …

Nef, an accessory protein of the Human Immunodeficiency Virus type 1 (HIV-1), is
dispensable for viral replication in cell culture, but promotes virus replication and …