The essential task of a germinal centre reaction is the selection of those B cells that bind the
antigen with high affinity. The exact mechanisms of B cell selection is still unknown and …

Affinity maturation of humoral responses to T-cell-dependent antigens occurs in germinal
centers (GC). In GCs antigen-specific B cells undergo rounds of somatic mutations that alter …

Mathematical modeling of complex biological systems has been shown to lead to
contradictory results. Two completely different approaches are compared using a highly …

Affinity maturation of antibodies during immune responses is achieved by multiple rounds of
somatic hypermutation and subsequent preferential selection of those B cells that express B …

During an immune response, the affinity of antibodies that react with the antigen that
triggered the response increases with time, a phenomenon known as affinity maturation. The …

The germinal centre reaction selects B cells from a large diversity of clones in order to
optimise the efficiency of an immune response. We discuss two rather different approaches …

We present a mathematical model which reproduces experimental data on the germinal
centre (GC) kinetics of the primed primary immune response and on affinity maturation …

Germinal centres (GCs) are the sites where V-gene hypermutation and B cell selection are
taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen …

From the old good times in which pioneering immunologists were simply specialised in
either T or B lymphocytes, to the current lymphoid complexities that powerful quantitative …

We devise a mathematical model to study germinal center (GC) kinetics. Earlier models for
GC kinetics are extended by explicitly modeling 1) the cell division history of centroblasts, 2) …