Tuberculosis pathogenesis and immunity

JA Philips, JD Ernst - Annual Review of Pathology: Mechanisms …, 2012 - annualreviews.org
Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …

The immunology of tuberculosis: from bench to bedside

K Dheda, SK Schwander, B Zhu, RN van Zyl‐Smit… - …, 2010 - Wiley Online Library
Tuberculosis (TB) is an international public health priority and kills almost two million people
annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and …

Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Clinical manifestations and immune response to tuberculosis

ML Carabalí-Isajar, OH Rodríguez-Bejarano… - World Journal of …, 2023 - Springer
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …

Pro-and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis

MP Etna, E Giacomini, M Severa, EM Coccia - Seminars in immunology, 2014 - Elsevier
A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

The immune landscape in tuberculosis reveals populations linked to disease and latency

E Esaulova, S Das, DK Singh, JA Choreno-Parra… - Cell host & …, 2021 - cell.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …

Innate Immunity to Mycobacterium tuberculosis

R van Crevel, THM Ottenhoff… - Clinical microbiology …, 2002 - Am Soc Microbiol
The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells

JK Sia, M Georgieva… - Journal of immunology …, 2015 - Wiley Online Library
Tuberculosis (TB) remains a serious global public health problem that results in up to 2
million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis …

Human immunology of tuberculosis

TJ Scriba, AK Coussens, HA Fletcher - Microbiology spectrum, 2017 - Am Soc Microbiol
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …

How can immunology contribute to the control of tuberculosis?

SHE Kaufmann - Nature Reviews Immunology, 2001 - nature.com
Tuberculosis poses a significant threat to mankind. Multidrug-resistant strains are on the
rise, and Mycobacterium tuberculosis infection is often associated with human …