T cells are essential for the adaptive immune response to pathogens. However,
dysfunctional T cell activity has been implicated in numerous diseases, including the failure …

The adaptor protein LAT has a prominent role in the transduction of intracellular signals
elicited by the TCR/CD3 complex. Upon TCR engagement, LAT becomes tyrosine …

Engaged T cell antigen receptors (TCRs) initiate signaling through the adaptor protein Lat.
In quiescent T cells, Lat is segregated into clusters on the cell surface, which raises the …

The integral membrane adaptor protein linker for activation of T cells (LAT) couples the T-
cell receptor (TCR) with downstream signalling and is essential for T-cell development and …

Engagement of the T cell receptor leads to activation of several tyrosine kinases and
phosphorylation of many intracellular proteins. This is followed by Ca2+ Copyright 2000 …

Adapter molecules in a variety of signal transduction systems link receptors to a limited
number of commonly used downstream signaling pathways. During T‐cell development and …

Transmembrane adaptor proteins (TRAPs) link antigen receptor engagement to downstream
cellular processes. Although these proteins typically lack intrinsic enzymatic activity, they are …

The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are
vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple …

LAT (linker for activation of T cells) is a transmembrane adaptor protein that plays an
essential role in TCR-mediated signaling and thymocyte development. Because LAT …

The antigen receptors on T and B lymphocytes (TCR and BCR) are multimeric complexes
composed of a receptor module associated with various signaling proteins (CD3 γδε, and …