Engagement of the T-cell receptor (TCR) complex initiates a cascade of intracellular events
ultimately leading to T-cell proliferation and differentiation. One of the first detectable …

In this study, we present the further characterization of a mutant Jurkat T cell line, J. CaM2,
that is defective in TCR-mediated signal transduction. Although initial TCR-mediated …

The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further
understand the functions of this protein, we performed yeast two-hybrid screening using …

The integral membrane protein linker for activation of T cells (LAT) is a central adapter
protein in the T-cell receptor (TCR)-mediated signaling pathways. The cellular localization of …

Signals emanating from antigen receptors critically regulate immune cell activation, survival,
and differentiation. Transmembrane adapter proteins (TRAPs), a group of molecules that …

Background The activation induced T cell specific adapter protein (TSAd), encoded by
SH2D2A, interacts with and modulates Lck activity. Several transcript variants of TSAd …

Mature T cells must discriminate between brief interactions with self-peptides and prolonged
binding to agonists. The kinetic proofreading model posits that certain T-cell antigen …

The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR
engagement. Phosphorylated LAT binds many critical signaling molecules. The central role …

Innate immune engagement results in the activation of host defenses that produce microbe-
specific inflammatory responses. A long-standing interest in the field of innate immunity is to …

Part 2 of this review on cellular activation by the T-cell antigen receptor (TCR) will highlight
how TCR signaling pathways are adapted to achieve specific biologic outcomes, including …