Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
Natural killer (NK) cells directly lyse tumor or viral-infected cells but also an important role for
NK cell cytotoxicity in regulating the extent of immune responses is emerging. Here, we …
NK cell cytotoxicity in regulating the extent of immune responses is emerging. Here, we …
JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis
Dendritic cells (DC) sense infection in their local microenvironment and respond
appropriately in order to induce T cell immunity. This response is mediated in part via the …
appropriately in order to induce T cell immunity. This response is mediated in part via the …
Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity
N Bhatnagar, HS Hong… - Blood, The Journal …, 2010 - ashpublications.org
Natural killer (NK) cells and polymorphonuclear cells (PMNs) play a critical role in the first
line of defense against microorganisms. Upon host infection, PMNs phagocytose invading …
line of defense against microorganisms. Upon host infection, PMNs phagocytose invading …
CD56dimCD16+ NK cells downregulate CD16 following target cell induced activation of matrix metalloproteinases
B Grzywacz, N Kataria, MR Verneris - Leukemia, 2007 - nature.com
Natural killer (NK) cells are immune effector cells that recognize both virally infected and
malignant target cells. Unlike T and B cells, NK cells, do not belong to the adaptive immune …
malignant target cells. Unlike T and B cells, NK cells, do not belong to the adaptive immune …
CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell‐mediated cytotoxicity
Triggering of cytotoxicity in human NK cells is induced by the combined engagement of
several triggering receptors. These include primary receptors such as NKG2D and the …
several triggering receptors. These include primary receptors such as NKG2D and the …
Regulatory NK-cell functions in inflammation and autoimmunity
A Lünemann, JD Lünemann, C Münz - Molecular medicine, 2009 - Springer
Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid
killing of infected and transformed cells without preactivation provides a first line of defense …
killing of infected and transformed cells without preactivation provides a first line of defense …
Expression of the CD80 and CD86 molecules enhances cytotoxicity by human natural killer cells
I Luque, H Reyburn, JL Strominger - Human Immunology, 2000 - Elsevier
In contrast to the inhibitory pathway of NK cell regulation, much less is known about
stimulatory or activation signals in NK cells. Both CD80 and CD86 function as costimulatory …
stimulatory or activation signals in NK cells. Both CD80 and CD86 function as costimulatory …
[HTML][HTML] Lineage-restricted function of nuclear factor κB–inducing kinase (NIK) in transducing signals via CD40
N Garceau, Y Kosaka, S Masters… - The Journal of …, 2000 - ncbi.nlm.nih.gov
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral
and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) …
and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) …
CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells
A Kurioka, C Cosgrove, Y Simoni… - Frontiers in …, 2018 - frontiersin.org
CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells;
however, the significance of CD161 expression on NK cells has not been comprehensively …
however, the significance of CD161 expression on NK cells has not been comprehensively …
Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity
P Le Bouteiller, A Barakonyi… - Proceedings of the …, 2002 - National Acad Sciences
Circulating human natural killer (NK) lymphocytes have been functionally defined by their
ability to exert cytotoxic activity against MHC class I-negative target cell lines, including …
ability to exert cytotoxic activity against MHC class I-negative target cell lines, including …