Natural killer (NK) cells directly lyse tumor or viral-infected cells but also an important role for
NK cell cytotoxicity in regulating the extent of immune responses is emerging. Here, we …

Dendritic cells (DC) sense infection in their local microenvironment and respond
appropriately in order to induce T cell immunity. This response is mediated in part via the …

Natural killer (NK) cells and polymorphonuclear cells (PMNs) play a critical role in the first
line of defense against microorganisms. Upon host infection, PMNs phagocytose invading …

Natural killer (NK) cells are immune effector cells that recognize both virally infected and
malignant target cells. Unlike T and B cells, NK cells, do not belong to the adaptive immune …

Triggering of cytotoxicity in human NK cells is induced by the combined engagement of
several triggering receptors. These include primary receptors such as NKG2D and the …

Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid
killing of infected and transformed cells without preactivation provides a first line of defense …

In contrast to the inhibitory pathway of NK cell regulation, much less is known about
stimulatory or activation signals in NK cells. Both CD80 and CD86 function as costimulatory …

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral
and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) …

CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells;
however, the significance of CD161 expression on NK cells has not been comprehensively …

Circulating human natural killer (NK) lymphocytes have been functionally defined by their
ability to exert cytotoxic activity against MHC class I-negative target cell lines, including …