The endocytosis of the human CD38 molecule has been investigated in normal lymphocytes
and in a number of leukemia-and lymphoma-derived cell lines. CD38 internalization was …

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral
and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) …

During the innate immune response to infection, monocyte-derived cytokines (monokines),
stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important …

Lymphocyte activation induces or increases the expression of several surface structures,
none of which is characteristic of an activated cell subset. In particular, structures such as …

Natural killer (NK) cells control the early phases of viral infections, modulate antigen-specific
immune responses, and participate in the rejection of tumours and bone marrow grafts. A …

The mechanism (s) of natural killer (NK) cell-mediated cytotoxicity (CMC) remains largely
unknown. In this study, we investigated the possibility of human NK cells to exhibit an …

ABSTRACT NK cells control tumor and virus-infected cells through releasing cytotoxic
granules and proinflammatory cytokines. IFN-γ and TNF-α secretions and cytotoxicity are …

Limited information is available on the surface molecules that are involved in natural killer
(NK) cell triggering. In this study, we selected the BAB281 monoclonal antibody (mAb) on …

Natural killer (NK) cells express two distinct surface receptors capable of triggering cytolytic
effector function. The first is CD 16, an immunoglobulin Fc receptor that allows NK cells to …

Human CD38 is a surface glycoprotein expressed by different immuno‐competent cells such
as immature and activated lymphocytes, plasma cells and natural killer cells. It has recently …