Both extracellular signal-regulated kinase (ERK) and c-Jun NH 2-terminal kinase (JNK)
have been implicated in mediating the signaling events that precede apoptosis. We studied …

The spontaneous regression of AK-5 histiocytoma is mediated by natural killer (NK) cells
through antibody-dependent cell-mediated cellular cytotoxicity (ADCC) and the target cell …

Natural killer (NK) cells have the dual ability to produce pro-inflammatory (IFNγ) and anti-
inflammatory (IL-10) cytokines during systemic infection, which points to their crucial role …

IL-2-activated NK cells exhibit cytotoxic activity against a wide variety of tumor cells in a non-
MHC-restricted fashion and in the absence of prior sensitization. The molecular mechanisms …

Despite the importance of natural killer (NK) cells in the immune response, the regulation of
human NK cell growth has not been well characterized. We have hypothesized that, similar …

The 5th international CD38 meeting, held in Torino, Italy, spanned a range of topics from the
role of CD38 as a signaling receptor In lymphocytic tumors to the importance of CD38 …

Abstract The MAPKs ERK, JNK, and p38 control diverse aspects of the immune response,
including regulation of cytotoxin biology in NK cells and CTL. The chemokine CCL5 is …

Natural killer (NK) cell-mediated cytotoxicity is triggered by multiple activating receptors
associated with the signaling adaptor protein DNAX activation protein 12/killer cell-activating …

In an attempt to identify a molecule in target recognition by CD3-large granular lymphocytes
(LGL), we have generated a rabbit antiidiotypic (anti-ID) serum against a monoclonal …

Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell
surface ligands that are induced preferentially or exclusively on these cells. These ligands …