Alzheimer's disease (AD) is a senile dementia characterized by amyloid plaques,
neurofibrillary tangles, and synaptic and cell loss. The “amyloid cascade” hypothesis …

Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …

Brain-derived neurotrophic factor (BDNF) is a versatile neurotrophic factor that has been
implicated in cell survival, cell differentiation, axonal growth, and activity-dependent synaptic …

Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Astrocytes, the most abundant type of glia in the brain, are considered to play a key role in
Alzheimer's disease (AD) pathologies. In a cell culture study, we have previously shown that …

In Alzheimer's disease, accumulation of amyloid-β (Aβ) is associated with loss of brain-
derived neurotrophic factor (BDNF), synapses, and memory. Previous work demonstrated …

Brain-derived neurotrophic factor (BDNF) is a critical molecule for learning and memory.
Brain BDNF levels correlate with cognitive status. BDNF is downregulated in Alzheimer's …

Brain derived neurotrophic factor (BDNF) promotes cholinergic neuron function and survival.
In Alzheimer's disease, BDNF mRNA and protein are decreased in basal forebrain …

Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …

Brain-derived neurotrophic factor (BDNF) plays pivotal roles in neuronal function. The
cleaved–mature–form of BDNF (mBDNF), predominantly expressed in adult brains, critically …