The Wnt/β-catenin pathway is crucial in normal development and throughout life, but
aberrant activation of this pathway has been linked to kidney fibrosis, although the …

Activation of the renin-angiotensin system (RAS) plays an essential role in the pathogenesis
of CKD and cardiovascular disease. However, current anti-RAS therapy only has limited …

The Wnt gene family, which encodes secreted growth and differentiation factors, has been
implicated in kidney organogenesis. The Wnts control both ureteric bud development and …

Epithelial-mesenchymal transition (EMT) is defined as a process in which differentiated
epithelial cells undergo phenotypic transformation into myofibroblasts capable of producing …

The Wnt/β-catenin signaling cascade is an evolutionarily conserved, highly complex
pathway that is known to be involved in kidney injury and repair after a wide variety of …

WNT signaling is a fundamental molecular pathway in both embryogenesis and disease.
Nephron development is dependent on WNT signaling. The nephron epithelia proximal to …

Several Wnt proteins are expressed in the embryonic kidney during various stages of
development. Gene knockout models and ex vivo studies have provided strong evidence …

Because fibrotic kidneys exhibit aberrant activation of β-catenin signaling, this pathway may
be a potential target for antifibrotic therapy. In this study, we examined the effects of β …

Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney
diseases and is associated with podocyte injury and proteinuria; however, the mechanisms …

Transforming growth factor β1 (TGF-β) promotes renal interstitial fibrosis in vivo and the
expression of mesenchymal genes in vitro; however, most of its direct targets in epithelial …