C-type natriuretic peptide (CNP) regulates salt excretion, vascular tone, and fibroblast
proliferation and activation. CNP inhibits fibroblast activation in vitro and fibrosis in vivo, but …

Wnt/β-catenin is a developmental signaling pathway that plays a crucial role in driving
kidney fibrosis after injury. Activation of β-catenin is presumed to be regulated through the …

Acute kidney injury (AKI) portends a poor clinical prognosis and increases the risk for the
development of chronic kidney disease (CKD). Currently, there are no therapies to treat AKI …

Renal fibrosis is the culmination of processes driven by signaling pathways involving
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …

Wnt-4 is a secreted glycoprotein that is critical for genitourinary development but found only
in the most distal collecting duct epithelium in the normal murine adult kidney. Wnt4 …

Mammalian nephrons form as a result of a complex morphogenesis and patterning of a
simple epithelial precursor, the renal vesicle. Renal vesicles are established from a …

A variety of chronic kidney diseases exhibit reactivation of Wnt/β-catenin signaling. In some
tissues, β-catenin transcriptionally regulates matrix metalloproteinase-7 (MMP-7), but the …

Activated Wnt signaling is critical in the pathogenesis of renal fibrosis, a final common
pathway for most forms of chronic kidney disease. Therapeutic intervention by inhibition of …

Wnt/β-catenin signaling and renin–angiotensin system in chro... : Current Opinion in
Nephrology and Hypertension Wnt/β-catenin signaling and renin–angiotensin system in …

TGF-β is a key profibrotic factor, but targeting TGF-β to prevent fibrosis also abolishes its
protective anti-inflammatory effects. Here, we investigated the hypothesis that we can …