Renin-angiotensin system (RAS) plays a key role in the development and progression of
chronic kidney disease (CKD). Recent studies have demonstrated activation of Wnt/β …

The mammalian kidney undergoes cell interactions between the epithelium and
mesenchyme to form the essential filtration unit of the kidney, termed the nephron. A third …

Cell-cell communication via Wnt ligands is necessary in regulating embryonic development
and has been implicated in CKD. Because Wnt ligands are ubiquitously expressed, the …

Imbalance of Wnt/β-catenin signaling in renal cells is associated with renal dysfunction, yet
the precise mechanism is poorly understood. Previously we observed activated Wnt/β …

The canonical WNT signaling pathway plays a crucial role in patterning of the embryo during
development, but little is known about the specific developmental events which are under …

The kidney is a key organ in the human body that excretes toxins and sustains the water–
electrolyte balance. During embryonic development and disease progression, the kidney …

The (pro) renin receptor (PRR) is a transmembrane protein with multiple functions. However,
its regulation and role in the pathogenesis of CKD remain poorly defined. Here, we report …

Abstract Development of the metanephric kidney is a complicated process regulated by
reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate …

Wnt proteins are required for induction of nephrons in mouse metanephric kidneys, but the
downstream pathways that mediate tubule induction and epithelial differentiation have …

The Wnt/β-catenin signaling pathway plays an important role in renal development and is
reexpressed in the injured kidney and other organs. β-Catenin signaling is protective in …