Injury to the adult kidney induces a number of developmental genes thought to regulate
repair, including Wnt4. During kidney development, early nephron precursors and medullary …

β-Catenin is a unique intracellular protein functioning as an integral component of the cell–
cell adherens complex and a principal signaling protein mediating canonical Wnt signaling …

The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how
these growth factors affect the epithelial response to CKD is not well studied. TGF-β has …

Chronic kidney disease (CKD) encompasses a group of diverse diseases that are
associated with accumulating kidney damage and a decline in glomerular filtration rate …

Podocytes are unique, highly specialized, terminally differentiated cells that are integral
components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety …

The Wnt signaling pathway is central to the development of all animals and to cancer
progression, yet largely unknown are the pairings of secreted Wnt ligands to their respective …

AKI with incomplete epithelial repair is a major contributor to CKD characterized by
tubulointerstitial fibrosis. Injury–induced epithelial secretion of profibrotic factors is …

The Wnt-β-catenin pathway plays key roles in embryogenesis. Wnt-4 is known to be
expressed in the mesonephric duct in embryonic development. It is tempting to speculate …

Objective The canonical WNT pathway has been implicated as playing important roles in the
pathogenesis of a variety of kidney diseases. Recently, WNT pathway activity was reported …

Abnormal differentiation of the renal stem/progenitor pool into kidney tissue can lead to renal
hypodysplasia (RHD), but the underlying causes of RHD are not well understood. In this …