Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling
plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants …

Proper development of nephrons is essential for kidney function. β-Catenin-independent
Wnt signaling through Fzd8, Inversin, Daam1, RhoA and Myosin is required for nephric …

Recent studies implicate Wnt/β-catenin signaling in podocyte dysfunction. Because vitamin
D analogs can inhibit β-catenin in other tissues, we tested whether the vitamin D analog …

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2
diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease …

About one fourth of people diagnosed with kidney cancer in 2007, are expected to die of this
disease within 5 years from the date of diagnosis. Recent years have produced novel drugs …

Members of the Wnt family of secreted glycoproteins act as short‐range signaling molecules
in vertebrate embryogenesis. Previous work has shown that Wnt‐4 is required for kidney …

The aim of this study was to characterize the mechanism of transforming growth factor (TGF)-
β1-mediated alteration of renal proximal tubular cell phenotype. TGF-β1 altered cell …

Abstract Epithelial-mesenchymal transition (EMT), a process by which differentiated
epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing …

A number of Wnt genes are expressed during, and are known to be essential for, early
kidney development. It is typically assumed that their products will act through the canonical …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …