Renal fibrosis is a common pathway for the progression of all chronic kidney diseases to
end‐stage kidney disease. Studies show that WNT1‐inducible signaling pathway protein‐1 …

Several studies have provided clear evidence of the importance of Wnt signaling in the
function of several tissues. Wnt signaling has been related to several cellular processes …

Formation of a functional kidney depends on the balance between renewal and
differentiation of nephron progenitors. Failure to sustain this balance can lead to kidney …

Chronic kidney disease (CKD) is a public health problem driven by myofibroblast
accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized …

The phenotypic heterogeneity and functional diversity of macrophages confer on them
complexed roles in the development and progression of kidney diseases. After kidney injury …

Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …

Development of the mammalian kidney is initiated by ingrowth of the ureteric bud into the
metanephric blastema. In response to signal (s) from the ureter, mesenchymal cells …

Classical in vitro studies indicate that tubule induction in the kidney mesenchyme is
mediated by cell-cell contacts between the inducer tissue and the metanephric …

Renal dysplasia, defined by defective ureteric branching morphogenesis and
nephrogenesis, is the major cause of renal failure in infants and children. Here, we define a …

Wnt4, a member of the Wnt superfamily of signaling molecules, is critical for mammalian
kidney development, since nephrogenesis fails in its absence, while Wnt4 signaling induces …