It is widely accepted that gastric parameters such as gastric distention provide a direct
negative feedback signal to inhibit eating; moreover, gastric and intestinal signals have …

The present review summarizes the appetite suppressing effects of PYY and GLP-1 in the
regulation of food intake in humans. Current evidence supports a role for gastrointestinal …

The slowing of gastric emptying is an important mechanism for the satiating effect of gut
peptide signaling. After food intake, cholecystokinin (CCK), as well as glucagon-like peptide …

Previous observations suggest that glucagon-like peptide-1 (GLP-1) is released into the
bloodstream only when dietary carbohydrate enters the duodenum at rates that exceed the …

Distension and chemosensitization of the stomach are insufficient to induce a ghrelin
response, suggesting that postgastric feedback is required. This postgastric feedback may …

In response to luminal food stimuli during meals, enteroendocrine cells release
gastrointestinal (GI) peptides that have long been known to control secretory and motor …

In vitro, both carbohydrate sugars and artificial sweeteners (AS) stimulate the secretion of
glucagon-like peptide-1 (GLP-1). It has been suggested that the gut tastes sugars and AS …

In cell line and animal models, sweet and bitter tastants induce secretion of signaling
peptides (eg, glucagon-like peptide-1 and cholecystokinin) and slow gastric emptying (GE) …

Satiety and satiety-regulating gut hormone levels are abnormal in hyperglycemic
individuals. We aimed to determine whether these abnormalities are secondary to …

The recently discovered gut peptide glucagon-like peptide-1 (GLP-1) is one of many
peptides implicated in the short-term regulation of appetite. GLP-1 is a 30-amino-acid …