Potential approaches to reverse or repair renal fibrosis

D Tampe, M Zeisberg - Nature Reviews Nephrology, 2014 - nature.com
The concept of reversing chronic kidney disease (CKD) has been intensively researched
over the past decade. Indeed, as the prevalence of end-stage renal disease is constantly on …

Anti-fibrotic treatments: a review of clinical evidence

M Allinovi, L De Chiara, ML Angelotti, F Becherucci… - Matrix Biology, 2018 - Elsevier
Renal fibrosis is a condition characterized by excessive extracellular matrix accumulation in
the kidney. Representing the final common result of a variety of injuries, it can lead to …

New therapies for the treatment of renal fibrosis

F Liu, S Zhuang - Renal fibrosis: mechanisms and therapies, 2019 - Springer
Renal fibrosis is the common pathway for progression of chronic kidney disease (CKD) to
end stage of renal disease. It is now widely accepted that the degree of renal fibrosis …

Targeting the progression of chronic kidney disease

M Ruiz-Ortega, S Rayego-Mateos, S Lamas… - Nature Reviews …, 2020 - nature.com
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

[HTML][HTML] The management of CKD: a look into the future

A Khwaja, M El Kossi, J Floege, M El Nahas - Kidney international, 2007 - Elsevier
The increasing global prevalence of chronic kidney disease (CKD) and end-stage renal
disease with the associated spiraling cost has profound public health and economic …

Treatment of renal fibrosis—turning challenges into opportunities

BM Klinkhammer, R Goldschmeding, J Floege… - Advances in chronic …, 2017 - Elsevier
Current treatment modalities are not effective in halting the progression of most CKD. Renal
fibrosis is a pathological process common to all CKD and thereby represents an excellent …

Acute kidney injury and maladaptive tubular repair leading to renal fibrosis

SMW Yu, JV Bonventre - Current opinion in nephrology and …, 2020 - journals.lww.com
Acute kidney injury and maladaptive tubular repair leading t... : Current Opinion in Nephrology
and Hypertension Acute kidney injury and maladaptive tubular repair leading to renal fibrosis …

Novel insights into renal fibrosis

F Eitner, J Floege - Current opinion in nephrology and …, 2003 - journals.lww.com
Novel insights into renal fibrosis : Current Opinion in Nephrology and Hypertension Novel
insights into renal fibrosis : Current Opinion in Nephrology and Hypertension Log in or Register …

Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets

W Lv, GW Booz, Y Wang, F Fan, RJ Roman - European journal of …, 2018 - Elsevier
Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …