Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms

FM Faraci, C Lynch… - American Journal of …, 2004 - journals.physiology.org
ADP mediates platelet-induced relaxation of blood vessels and may function as an important
intercellular signaling molecule in the brain. We used pharmacological and genetic …

Endothelium-dependent responses of cerebral arterioles to adenosine 5'-diphosphate

WG Mayhan - Journal of vascular research, 1992 - karger.com
The goal of this study was to determine the role of endothelium-derived relaxing factor
(EDRF) in dilatation of cerebral arterioles in response to adenosine 5'-diphosphate (ADP) …

Agonist-specific differences in mechanisms mediating eNOS-dependent pial arteriolar dilation in rats

HL Xu, DL Feinstein, RA Santizo… - American Journal …, 2002 - journals.physiology.org
Nitric oxide (NO), derived from the endothelial isoform of NO synthase (eNOS), is a vital
mediator of cerebral vasodilation. In the present study, we addressed the issue of whether …

cGMP-dependent and not cAMP-dependent kinase is required for adenosine-induced dilation of intracerebral arterioles

GA West, JR Meno, TSK Nguyen, AC Ngai… - Journal of …, 2003 - journals.lww.com
Adenosine (ADO) is a potent cerebral vasodilator and has been proposed as a metabolic
regulator of cerebral blood flow. However, the signal transduction pathway by which ADO …

Possible role of glia in the induction of CNS-like properties in aortic endothelial cells: ATP-activated channels

D Janigro, KA Stanness, TS Nguyen… - Adenosine and Adenine …, 1995 - Springer
Vascular endothelial cells provide a monolayer surface that lines the lumen of blood
vessels. Due to their anatomic proximity to both smooth muscle and brain parenchyma cells …

Endothelium-dependent regulation of cerebrovascular tone by extracellular and intracellular ATP

D Janigro, TS Nguyen, J Meno… - American Journal of …, 1997 - journals.physiology.org
ATP receptors and ATP-sensitive potassium channels (KATP) are expressed in vascular
smooth muscle (VSM) and endothelial cells (EC). In isolated penetrating vessels, ATP …

Functional heterogeneity of endothelial P2 purinoceptors in the cerebrovascular tree of the rat

J You, TD Johnson, SP Marrelli… - American Journal of …, 1999 - journals.physiology.org
The effects of stimulating P2Y1 or P2Y2 purinoceptors on the endothelium of isolated middle
cerebral arteries (MCAs), third-order branches of the MCA (bMCAs), and penetrating …

Role of NAD (P) H Oxidase in Alcohol-Induced Impairment of Endothelial Nitric Oxide Synthase–Dependent Dilation of Cerebral Arterioles

H Sun, H Zheng, E Molacek, Q Fang, KP Patel… - Stroke, 2006 - Am Heart Assoc
Background and Purpose—Our goal was to determine whether NAD (P) H oxidase is
involved in impaired endothelial nitric oxide synthase (eNOS)–dependent reactivity of …

Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress

WG Mayhan, DM Arrick, GM Sharpe, H Sun - Microcirculation, 2008 - Taylor & Francis
Objective: Our goal was to identify the role of oxidative stress via activation of NAD (P) H
oxidase in cerebrovascular dysfunction in aged rats. Methods: We examined the reactivity of …

Mechanisms That Produce Nitric Oxide–Mediated Relaxation of Cerebral Arteries During Atherosclerosis

SP Didion, DD Heistad, FM Faraci - Stroke, 2001 - Am Heart Assoc
Background and Purpose—The first goal of the present study was to examine the hypothesis
that relaxation of cerebral arteries to nitric oxide in primates is dependent on activation of …