ADP mediates platelet-induced relaxation of blood vessels and may function as an important
intercellular signaling molecule in the brain. We used pharmacological and genetic …

The goal of this study was to determine the role of endothelium-derived relaxing factor
(EDRF) in dilatation of cerebral arterioles in response to adenosine 5'-diphosphate (ADP) …

Nitric oxide (NO), derived from the endothelial isoform of NO synthase (eNOS), is a vital
mediator of cerebral vasodilation. In the present study, we addressed the issue of whether …

Adenosine (ADO) is a potent cerebral vasodilator and has been proposed as a metabolic
regulator of cerebral blood flow. However, the signal transduction pathway by which ADO …

Vascular endothelial cells provide a monolayer surface that lines the lumen of blood
vessels. Due to their anatomic proximity to both smooth muscle and brain parenchyma cells …

ATP receptors and ATP-sensitive potassium channels (KATP) are expressed in vascular
smooth muscle (VSM) and endothelial cells (EC). In isolated penetrating vessels, ATP …

The effects of stimulating P2Y1 or P2Y2 purinoceptors on the endothelium of isolated middle
cerebral arteries (MCAs), third-order branches of the MCA (bMCAs), and penetrating …

Background and Purpose—Our goal was to determine whether NAD (P) H oxidase is
involved in impaired endothelial nitric oxide synthase (eNOS)–dependent reactivity of …

Objective: Our goal was to identify the role of oxidative stress via activation of NAD (P) H
oxidase in cerebrovascular dysfunction in aged rats. Methods: We examined the reactivity of …

Background and Purpose—The first goal of the present study was to examine the hypothesis
that relaxation of cerebral arteries to nitric oxide in primates is dependent on activation of …