Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine
R Greco, C Demartini, M Francavilla, AM Zanaboni… - Cells, 2022 - mdpi.com
Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …
more specifically in the mechanisms underlying peripheral and central sensitization. Here …
The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine
PL Durham, CV Vause - CNS drugs, 2010 - Springer
Based on preclinical and clinical studies, the neuropeptide calcitonin gene-related peptide
(CGRP) is proposed to play a central role in the underlying pathology of migraine. CGRP …
(CGRP) is proposed to play a central role in the underlying pathology of migraine. CGRP …
Diverse physiological roles of calcitonin gene-related peptide in migraine pathology: modulation of neuronal-glial-immune cells to promote peripheral and central …
PL Durham - Current pain and headache reports, 2016 - Springer
The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying
pathology of migraine by promoting the development of a sensitized state of primary and …
pathology of migraine by promoting the development of a sensitized state of primary and …
CGRP receptor antagonism and migraine
L Edvinsson, TW Ho - Neurotherapeutics, 2010 - Elsevier
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral
nervous systems, consistent with control of vasodilatation, nociception, motor function …
nervous systems, consistent with control of vasodilatation, nociception, motor function …
CGRP receptors in the control of pain and inflammation
Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain
transmission and inflammation and for these reasons to the mechanism of migraine. CGRP …
transmission and inflammation and for these reasons to the mechanism of migraine. CGRP …
Peripherally administered calcitonin gene–related peptide induces spontaneous pain in mice: Implications for migraine
BJ Rea, AS Wattiez, JS Waite, WC Castonguay… - Pain, 2018 - journals.lww.com
Migraine is the third most common disease in the world (behind dental caries and tension-
type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly …
type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly …
CGRP in human models of migraine
Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key
molecule. Provocation experiments have demonstrated that intravenous CGRP infusion …
molecule. Provocation experiments have demonstrated that intravenous CGRP infusion …
Calcitonin gene-related peptide (CGRP): a new target for migraine
AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …
Inhibition of calcitonin gene‐related peptide function: a promising strategy for treating migraine
PL Durham - Headache: The Journal of Head and Face Pain, 2008 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is implicated in the underlying
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …