Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine

R Greco, C Demartini, M Francavilla, AM Zanaboni… - Cells, 2022 - mdpi.com
Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine

PL Durham, CV Vause - CNS drugs, 2010 - Springer
Based on preclinical and clinical studies, the neuropeptide calcitonin gene-related peptide
(CGRP) is proposed to play a central role in the underlying pathology of migraine. CGRP …

Diverse physiological roles of calcitonin gene-related peptide in migraine pathology: modulation of neuronal-glial-immune cells to promote peripheral and central …

PL Durham - Current pain and headache reports, 2016 - Springer
The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying
pathology of migraine by promoting the development of a sensitized state of primary and …

CGRP receptor antagonism and migraine

L Edvinsson, TW Ho - Neurotherapeutics, 2010 - Elsevier
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral
nervous systems, consistent with control of vasodilatation, nociception, motor function …

CGRP receptors in the control of pain and inflammation

S Benemei, P Nicoletti, JG Capone… - Current opinion in …, 2009 - Elsevier
Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain
transmission and inflammation and for these reasons to the mechanism of migraine. CGRP …

Peripherally administered calcitonin gene–related peptide induces spontaneous pain in mice: Implications for migraine

BJ Rea, AS Wattiez, JS Waite, WC Castonguay… - Pain, 2018 - journals.lww.com
Migraine is the third most common disease in the world (behind dental caries and tension-
type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly …

CGRP in human models of migraine

H Ashina, HW Schytz, M Ashina - Calcitonin Gene-Related Peptide …, 2019 - Springer
Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key
molecule. Provocation experiments have demonstrated that intravenous CGRP infusion …

Calcitonin gene-related peptide (CGRP): a new target for migraine

AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Inhibition of calcitonin gene‐related peptide function: a promising strategy for treating migraine

PL Durham - Headache: The Journal of Head and Face Pain, 2008 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is implicated in the underlying
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …