Mind the gaps: functional networks disrupted by white matter hyperintensities are associated with greater falls risk

RA Crockett, CL Hsu, E Dao, R Tam, W Alkeridy… - Neurobiology of …, 2022 - Elsevier
White matter hyperintensities (WMH) are associated with greater falls risk and slow gait
speed. Whether these deficits are caused by the disruption of large-scale functional …

White matter hyperintensities are associated with falls in older people with dementia

ME Taylor, SR Lord, K Delbaere, W Wen… - Brain imaging and …, 2019 - Springer
Abstract White Matter Hyperintensities (WMHs) are associated with impaired gait, balance
and cognition and increased fall risk in cognitively healthy older people. However, few …

Brain white matter hyperintensities, executive dysfunction, instability, and falls in older people: a prospective cohort study

JJJ Zheng, SR Lord, JCT Close… - … Series A: Biomedical …, 2012 - academic.oup.com
Abstract Background. White matter hyperintensities (WMHs) are associated with fall risk
factors in older people including reduced cognitive functioning and impaired balance and …

Pathways linking regional hyperintensities in the brain and slower gait

N Bolandzadeh, T Liu-Ambrose, H Aizenstein, T Harris… - Neuroimage, 2014 - Elsevier
Importance Cerebral white matter hyperintensities (WMHs) are involved in the evolution of
impaired mobility and executive functions. Executive functions and mobility are also …

Progression of white matter hyperintensities of presumed vascular origin increases the risk of falls in older people

ML Callisaya, R Beare, T Phan… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. Greater volume of cerebral white matter hyperintensities (WMH) of presumed
vascular origin may affect postural control and gait. WMH measured at one time point …

The correlation between white matter hyperintensity and balance disorder and fall risk: An observational, prospective cohort study

DC Shen, SL Wu, YZ Shi, S Wang… - Chronic Diseases and …, 2016 - mednexus.org
Objective: The presence of an association between white matter hyperintensity (WMH) and
the risk of falls in older people is uncertain, with little supporting prospective evidence …

Differences in the association between white matter hyperintensities and gait performance among older adults with and without cognitive impairment

R Sakurai, H Inagaki, AM Tokumaru… - Geriatrics & …, 2021 - Wiley Online Library
Aim Gait impairment implies subtle cognitive impairment (CI) and is associated with severity
of white matter hyperintensities (WMHs). However, cognitive differences in such an …

Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review

JJJ Zheng, K Delbaere, JCT Close, PS Sachdev… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—White matter lesions (WMLs) are common findings on
neuroimaging in older people. This review systematically evaluates the published literature …

Impact of cerebral white matter changes on functionality in older adults: An overview of the LADIS Study results and future directions

L Pantoni, F Fierini, A Poggesi… - Geriatrics & …, 2015 - Wiley Online Library
The evidence on the clinical significance of cerebral white matter changes (WMC) has
mounted over the past few decades. WMC are recognized as one of the neuroimaging …

White matter hyperintensities, cognitive impairment and dementia: an update

ND Prins, P Scheltens - Nature Reviews Neurology, 2015 - nature.com
White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …