The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?

M Vergeer, AG Holleboom, JJP Kastelein… - Journal of lipid …, 2010 - ASBMB
There is unequivocal evidence of an inverse association between plasma high-density
lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a …

High density lipoproteins and coronary heart disease

PJ Barter, KA Rye - Atherosclerosis, 1996 - Elsevier
An inverse relationship between the concentration of high density lipoprotein (HDL)
cholesterol and the development of coronary heart disease (CHD) is well established. It is …

High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions

P Barter, J Kastelein, A Nunn, R Hobbs, FFE Board - Atherosclerosis, 2003 - Elsevier
The concentration of high density lipoprotein-cholesterol (HDL-C) has been found
consistently to be a powerful negative predictor of premature coronary heart disease (CHD) …

Atheroprotective effects of high-density lipoproteins

G Assmann, JR Nofer - Annual review of medicine, 2003 - annualreviews.org
Observational studies provide overwhelming evidence that a low high-density lipoprotein
(HDL)–cholesterol level increases the risk of coronary events, both in healthy subjects and …

HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis

EM Tsompanidi, MS Brinkmeier, EH Fotiadou… - Atherosclerosis, 2010 - Elsevier
Coronary heart disease (CHD) is a leading cause of death in western societies. In the last
few decades, a number of epidemiological studies have shown that a disproportion between …

High-density lipoproteins and atherosclerosis

DJ Rader - The American journal of cardiology, 2002 - Elsevier
High-density lipoproteins (HDLs) are strongly related to risk of atherosclerotic cardiovascular
disease. Low levels of HDL cholesterol are a major cardiovascular risk factor, and …

Novel insights from human studies on the role of high-density lipoprotein in mortality and noncardiovascular disease

CM Madsen, A Varbo… - … , thrombosis, and vascular …, 2021 - Am Heart Assoc
The vast majority of research about HDL (high-density lipoprotein) has for decades revolved
around the possible role of HDL in atherosclerosis and its therapeutic potential within …

HDL-cholesterol in coronary artery disease risk: function or structure?

Ó Pérez-Méndez, HG Pacheco, C Martínez-Sánchez… - Clinica Chimica …, 2014 - Elsevier
High-density lipoproteins (HDL) are inversely related with coronary artery disease (CAD)
and HDL-cholesterol is the only standardized and reproducible parameter available to …

HDL and cardiovascular risk: time to call the plumber?

B Hewing, KJ Moore, EA Fisher - Circulation research, 2012 - Am Heart Assoc
High-density lipoprotein cholesterol (HDL-C) has been dubbed the good cholesterol
because it is thought to reflect the ability of HDL particles to remove excess cholesterol …

Health benefits of high-density lipoproteins in preventing cardiovascular diseases

H Berrougui, CN Momo, A Khalil - Journal of clinical lipidology, 2012 - Elsevier
Plasma levels of high-density lipoprotein (HDL) are strongly and inversely correlated with
atherosclerotic cardiovascular diseases. However, it is becoming clear that a functional HDL …