Chronic inflammation results from dysregulated resolution mechanisms and causes
pathologies such as inflammation-associated colorectal cancer (I-CRC) and inflammatory …

Inflammation is a recognized hallmark of cancer that contributes to the development and
progression of colorectal cancer (CRC). Anti-inflammatory drugs currently used for the …

Simple Summary The evolution of cancer is strongly influenced by the context in which
tumor cells develop and grow, known as the tumor microenvironment (TME). The TME is …

The resolution of inflammation is an active process, guided by specialized pro-resolution
lipid mediators (SPMs). These mediators originate from polyunsaturated fatty acids, such as …

Chronic inflammatory diseases are the major cause of morbidity and mortality in the aging
population worldwide. Chronic inflammation reflects a deficiency in the resolution phase of …

Polyunsaturated fatty acids (PUFAs) are enzymatically converted to a variety of bioactive
products through insertion of molecular oxygen. PUFA-derived mediators can have either …

Inflammation is linked with carcinogenesis in many types of cancer including colorectal
cancer (CRC). Aspirin is recommended for the prevention of CRC, although the mechanism …

The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

Unresolved inflammation is central to the pathophysiology of commonly occurring vascular
diseases such as atherosclerosis, aneurysm, and deep vein thrombosis—conditions that are …

A precision medicine approach is widely acknowledged to yield more effective therapeutic
strategies in the treatment of patients with chronic inflammatory conditions than the …