Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2, 4‐dichloro) benzylidene] thiazolidine‐2, 4 …

K El‐Adl, AGA El‐Helby, H Sakr, RR Ayyad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. MCF‐7 was the most sensitive cell line to the cytotoxicity of the new …
被引用次数：50 相关文章 所有 3 个版本

Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2, 4‐dione derivatives as VEGFR‐2 inhibitors

K El‐Adl, H Sakr, SSA El‐Hddad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive …
被引用次数：36 相关文章 所有 3 个版本

5‐(4‐Methoxybenzylidene) thiazolidine‐2, 4‐dione‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations

K El‐Adl, H Sakr, M Nasser, M Alswah… - Archiv der …, 2020 - Wiley Online Library
Abstract A novel series of 5‐(4‐methoxybenzylidene) thiazolidine‐2, 4‐dione derivatives, 5a–
g and 7a–f, was designed, synthesized, and evaluated for their anticancer activity against …
被引用次数：41 相关文章 所有 3 个版本
[PDF] researchgate.net

Benzoxazole/benzothiazole‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations

AGA El‐Helby, H Sakr, IH Eissa… - Archiv Der …, 2019 - Wiley Online Library
A novel series of benzoxazole/benzothiazole derivatives 4a–c–11a–e were designed,
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …
被引用次数：90 相关文章 所有 4 个版本
[PDF] researchgate.net

Pyridine‐derived VEGFR‐2 inhibitors: rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking

NM Saleh, AAH Abdel‐Rahman, AM Omar… - Archiv der …, 2021 - Wiley Online Library
Abstract Novel pyridine‐derived compounds (5–19) were designed and synthesized, and
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …
被引用次数：29 相关文章 所有 4 个版本

Design, synthesis, molecular docking, and anticancer evaluations of 1‐benzylquinazoline‐2,4(1H,3H)‐dione bearing different moieties as VEGFR‐2 inhibitors

K El‐Adl, AGA El‐Helby, H Sakr… - Archiv der …, 2020 - Wiley Online Library
A novel series of 1‐benzylquinazoline‐2, 4 (1H, 3H)‐dione derivatives, 6a, b to 11a–e, was
designed, synthesized, and evaluated for their anticancer activity against HepG2, HCT‐116 …
被引用次数：43 相关文章 所有 3 个版本
[PDF] researchgate.net

Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors

AGA El‐Helby, H Sakr, IH Eissa… - Archiv der …, 2019 - Wiley Online Library
Novel series of benzoxazoles 4a‐f‐16 were designed, synthesized, and evaluated for
anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the most …
被引用次数：122 相关文章 所有 4 个版本

Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2, 4-dione derivatives targeting VEGFR-2 enzyme

K El-Adl, AGA El-Helby, H Sakr, IH Eissa… - Bioorganic …, 2020 - Elsevier
Abstract Novel series of 5-benzylidenethiazolidine-2, 4-dione derivatives 4 ac-8 af were
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
被引用次数：77 相关文章 所有 3 个版本

Design, synthesis, molecular docking, and anticancer activity of phthalazine derivatives as VEGFR‐2 inhibitors

AGA El‐Helby, RRA Ayyad, H Sakr… - Archiv der …, 2017 - Wiley Online Library
Novel series of phthalazine derivatives 6–11 were designed, synthesized, and evaluated for
their anticancer activity against two human tumor cell lines, HCT‐116 human colon …
被引用次数：64 相关文章 所有 3 个版本

Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma

IH Eissa, MK Ibrahim, AM Metwaly, A Belal… - Bioorganic …, 2021 - Elsevier
A series of new VEGFR-2 inhibitors were designed, synthesized and evaluated for their anti-
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
被引用次数：74 相关文章 所有 5 个版本