[HTML][HTML] Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
H Harada, S Itasaka, Y Zhu, L Zeng, X Xie… - British journal of …, 2009 - nature.com
Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …
[HTML][HTML] HIF-1 and tumour radiosensitivity
BJ Moeller, MW Dewhirst - British journal of cancer, 2006 - nature.com
Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …
Basal HIF-1 [alpha] expression levels are not predictive for radiosensitivity of human cancer cell lines
D Schilling, C Bayer, K Emmerich… - Strahlentherapie …, 2012 - search.proquest.com
High levels of hypoxia inducible factor (HIF)-1α in tumors are reported to be associated with
tumor progression and resistance to therapy. To examine the impact of HIF-1α on …
tumor progression and resistance to therapy. To examine the impact of HIF-1α on …
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
MW Dewhirst, Y Cao, B Moeller - Nature Reviews Cancer, 2008 - nature.com
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …
Hypoxia-inducible factor 1 in tumor radioresistance
Recent advances in radiotherapy technology now enable us to deliver a booster dose of
radiation to small target fractions in a malignant tumor. To fully exploit this technology in …
radiation to small target fractions in a malignant tumor. To fully exploit this technology in …
Cell type–specific association of hypoxia-inducible factor-1α (HIF-1α) protein accumulation and radiobiologic tumor hypoxia
D Vordermark, A Katzer, K Baier, P Kraft… - International Journal of …, 2004 - Elsevier
PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is currently
discussed as a potential endogenous marker of tumor hypoxia to select patients for modified …
discussed as a potential endogenous marker of tumor hypoxia to select patients for modified …
Stabilisation and knockdown of HIF-two distinct ways comparably important in radiotherapy
M Ströfer, W Jelkmann, E Metzen… - Cellular Physiology and …, 2011 - karger.com
Background: Radiotherapy is one of the most widely used treatments for cancer. The benefit
of radiation is known to be negatively affected by tumor hypoxia and the expression of …
of radiation is known to be negatively affected by tumor hypoxia and the expression of …
Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1
KJ Williams, BA Telfer, D Xenaki, MR Sheridan… - Radiotherapy and …, 2005 - Elsevier
BACKGROUND AND PURPOSE: To test the hypothesis that deficiency in expression of the
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient …
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient …
Cell-permeable hypoxia-inducible factor-1 (HIF-1) antagonists function as tumor radiosensitizers
M Shi, XT Guo, MG Shu, FL Chen, LW Li - Medical hypotheses, 2007 - Elsevier
Hypoxia is a common phenomenon in human solid tumors and has been considered as an
important, independent negative prognostic factor for response to treatment and survival of …
important, independent negative prognostic factor for response to treatment and survival of …
Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting
MW Dewhirst - Cancer research, 2007 - AACR
Abstract Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to
hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF …
hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF …