Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

The hypoxic condition is a common feature that negatively impacts the efficacy of radio-and
chemotherapy in solid tumors. Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate …

Tumour hypoxia represents a major obstacle to the success of radiotherapy and
chemotherapy. The discovery that the hypoxia-inducible factor 1 (HIF-1) is a master …

Abstract Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to
microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a …

Summary Background:: Hypoxia inducible factor-1 has been identified as a potential target
to overcome hypoxia-induced radioresistance The aim of the present study was to …

Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor
(HIF-1) creates a microenvironment and cancer cells' intrinsic signaling networks conferring …

Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour
progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia …

Tumor hypoxia negatively regulates cell growth and causes a more malignant phenotype by
increasing the expression of genes encoding angiogenic, metabolic and metastatic factors …

A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts
radiotherapy. As a result, there has been longstanding active research into novel methods of …

Overexpression of hypoxia‐inducible factor‐1α (HIF‐1α) in human tumors is associated with
poor prognosis and poor outcome to radiation therapy. Inhibition of HIF‐1α is considered as …