Purpose: Hypoxia-inducible factor-1α (HIF-1α) plays a pivotal role in the reaction of a tumour
to hypoxia. In this study, we examined the inhibitory effect of a natural compound, honokiol …

Targeting hypoxia-inducible factor-1 (HIF-1) active cells in tumors may be an excellent
strategy to improve the outcome of radiation therapy. On the basis of the reported role of YC …

Aims and background Hypoxia is a fundamental microenvironmental component of
osteosarcoma which induces activation of the hypoxia-inducible factor-1 (HIF-1) pathway …

PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is a key
regulatory element of the hypoxic response of cells. High protein levels have been linked to …

Hypoxia-inducible factor HIF-1 is responsible for radiation resistance and poor prognosis in
cancer therapy. As part of our drug discovery program, a novel HIF inhibitor, LW6, was …

Hypoxia is a common feature of many malignant neoplasms and has been identified as a
major reason for the radioresistance of malignant tumor tissue. On the other hand, the …

A decline in the tissue oxygen level below normal leads to cellular hypoxia. This situation is
very frequently encountered in solid tumors as existing blood vessels cannot satisfy the …

Human solid tumors contain hypoxic regions that have considerably lower oxygen tension
than the normal tissues. Hypoxia offers resistance to radiotherapy and anticancer …

We have previously shown that radiation increases HIF-1 activity in tumors, causing
significant radioprotection of the tumor vasculature. The impact that HIF-1 activation has on …

Hypoxia, a reduction in the normal level of tissue oxygen tension, occurs in most solid
tumors in regions where tumor growth outstrips new blood vessel formation. Hypoxic cancer …