Hypoxia-inducible factor-1α (HIF-1α) is believed to promote tumor growth, and thus, is
viewed as one of the most compelling cancer therapy targets. YC-1 is widely used as a …

Hypoxia-inducible factor-1 is a heterodimer made up of an oxygen-regulated HIF1α subunit
and a constitutively expressed HIF1β subunit. Among the 70 target genes of HIF-1 known so …

Abstract Hypoxia-inducible factor (HIF)-1 plays a key role in tumor promotion by inducing∼
60 genes required for tumor adaptation to hypoxia; thus, it is viewed as a target for cancer …

OBJECTIVE To determine the role of hypoxia‐inducible factor‐2α (HIF2α) on the sensitivity
of renal cell carcinoma (RCC) cell lines to ionizing radiation and to determine if the mTOR …

The transcription factor hypoxia‐inducible factor‐1α (HIF‐1α) is the key regulator that
controls the hypoxic response of mammalian cells. The overexpression of HIF‐1α has been …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Purpose: Hypoxia-inducible factors HIF1α and HIF2α (HIFαs) regulate the expression of a
variety of genes encoding proteins related to angiogenesis and to anaerobic metabolism of …

Hypoxia occurs in solid tumours due to a mismatch between tumour growth and
angiogenesis. Hypoxia in solid tumours is associated with an aggressive phenotype and …

Abstract Hypoxia-inducible factor-1 (HIF-1) is responsible for various gene expressions
related to tumor malignancy, such as metastasis, invasion and angiogenesis. Therefore …

Radiation plays an important role in the treatment of hepatoma. In order to improve its
therapeutic ratio, there has been much interest in augmenting the effect of radiation on …