Dependency on tumor oxygenation is one of the major features of radiation therapy and this
has led many radiation biologists and oncologists to focus on tumor hypoxia. The first …

Abstract Background Hypoxia-inducible factor-1 (HIF-1) overexpression has been linked to
tumor progression and poor prognosis. We investigated whether targeting of HIF-1 using …

Solid tumours contain regions of hypoxia, which may be a prognostic indicator and
determinant of malignant progression, metastatic development and chemoradio-resistance …

Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and
oncology since Thomlinson and Gray detected hypoxic cells in malignant solid tumors and …

Could a rational, hypothesis-driven and well-tolerated therapy drive tumor progression? This
scenario can be foreseen for antiangiogenic therapy, despite it is one of the most elegant …

Approximately 50% of cancer patients receive radiation treatment, either alone or in
combination with other therapies. Tumor hypoxia has long been associated with resistance …

Through a poorly understood mechanism, tumors respond to radiation by secreting
cytokines which inhibit endothelial cell apoptosis, thereby limiting treatment response by …

Hypoxia-inducible factor-1α (HIF-1α) is both a potential endogenous marker of tumor
hypoxia and therapeutic target, and elevated HIF-1α protein levels have been shown to be …

Transcriptional activity of HIF-1 (hypoxia-inducible factor-1) has been reported to be up-
regulated in solid tumors after ionizing radiation; however, the molecular mechanism …

The objective of this review is to examine the role that HIF-1 plays in the initiation of
angiogenesis and in radiotherapy response. Although these two phenomena may at first …