Background: Hypoxia-inducible factor 1 alpha (HIF-1α), a component of HIF-1, is expressed
in human tumors and renders cells able to survive and grow under hypoxic (low-oxygen) …

Like other tumors, lung cancer must induce angiogenesis as it grows. Hypoxia‐inducible
factor 1α (HIF‐1α) is the inducible subunit of the HIF‐1 transcription factor that regulates …

Glioblastoma multiforme (GBM) tumors are the most common type of brain tumors and
resistance to radiotherapy. This study aimed to investigate the differential effect and …

Abstract Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and
metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed …

Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response
to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear …

Solid tumors include hypoxic areas due to excessive cell proliferation. Adaptation to low
oxygen levels is mediated by the hypoxia-inducible factor (HIF) pathway promoting invasion …

The hypoxia-inducible factor 1 (HIF-1) is known to induce the expression of several proteins
linked to the maintenance of oxygen homeostasis, cellular energy metabolism, and tumor …

Hypoxia is a common feature in tumors associated with an increased resistance of tumor
cells to therapies. In addition to O2 diffusion–limited hypoxia, another form of tumor hypoxia …

The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1β and the
oxygen-responsive HIF-1α subunit, is the master activator of the cellular transcriptional …

Tumour recurrence frequently occurs after radiotherapy, but the characteristics,
intratumoural localization and post-irradiation behaviour of radioresistant cancer cells …