Mounting evidence has revealed a causative role of intermittent hypoxia (IH) in cancer
progression in mouse models of obstructive sleep apnea (OSA), but most studies have …

Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic
response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a …

Hypoxia has long been recognized as detrimental to the successful treatment of malignant
tumors with ionizing radiation. Because hypoxia-inducible factor (HIF)-1α plays an essential …

HIF‐1α plays a major role in activating gene transcription and is important for maintaining
homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF‐1α is a …

Hypoxia develops in the majority of solid tumors due to the inability of the existing vascular
system to supply the growing tumor mass with adequate amounts of oxygen. A large body of …

Background Hypoxia induces activation of the HIF-1 pathway and is an essential
characteristic of malignant gliomas. Hypoxia has been linked to tumor progression, therapy …

Purpose: To investigate the relations between hypoxia-inducible factor-1 (HIF-1), tumor
oxygenation, and clinical correlates in patients with locally advanced carcinoma of the …

Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its
critical role in radio-and chemoresistance and its significance as an adverse prognostic …

Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma
(HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy …

Purpose: We sought to determine whether hypoxia-induced radioresistance is mediated by
the transcription factor hypoxia-inducible factor-1α (HIF-1α). Methods and materials: We …