Hypoxia‐inducible factor‐1 (HIF‐1) is now recognized as a possible target for cancer
treatment. This transcription factor is responsible for the overexpression of several genes …

The hypoxia-inducible transcription factor, HIF-1, adapts cells to low oxygen tension. In
addition to the activation of angiogenesis by induction of VEGF, HIF-1 may trigger hypoxia …

All solid tumors experience some degree of hypoxia. The response to the stress of hypoxia
is mediated in large part by the hypoxia inducible factor-1 (HIF-1) transcription factor that …

The hypoxia-inducible factor (HIF) 1α is a key regulator of the cellular response to oxygen
deprivation. Specific disruption of the HIF-1 pathway is important for exploring its role in …

Hypoxia plays a major role in the induction of angiogenesis during tumor development. One
mechanism by which tumor cells respond to a reduced oxygen level is via the activation of …

Hypoxia‐inducible factors (HIFs) are transcription factors that activate the transcription of
genes necessary to circumvent to hypoxic (low oxygen level) environments. In …

Hypoxia is frequently observed in solid tumors and also one of the major obstacles for
effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to …

OBJECTIVE. Bioluminescence imaging is a powerful technique that has shown that hypoxia-
inducible factor 1 (HIF-1), a transcription factor that protects tumor cells from hypoxia, is up …

In general, tumors cells that are resistant to apoptosis and increase angiogenesis are a
result of the hypoxic responses contributing to the malignant phenotype. In this study, we …

The central component of hypoxia sensing in the cell is the hypoxia-inducible factor (HIF)
transcriptional complex. HIF activity is deregulated in many human cancers, especially those …