We analyzed DNA from 105 primary breast cancers to assess amplification of the ERBB2
gene and loss of heterozygosity (LOH) on chromosome 17 using 4 polymorphic markers …

In this study, we analyzed 105 paired sporadic primary breast tumor and normal tissue
samples for loss of heterozygosity (LOH) on chromosome 17, using 12 polymorphic markers …

Primary breast tumors were tested for loss of heterozygosity (LOH), on chromosome 9p with
microsatellite markers restricted to a 28 cM region including the MTS1 gene. LOH was found …

Recent studies have shown that chromosome 8p21-22 is the main site of frequent loss of
heterozygosity (LOH) in breast cancers. However, the detailed molecular analysis of …

Alterations of chromosome 7 are among the most frequent cytogenetic abnormalities found
in human breast carcinoma. We examined genetic changes on chromosome 7 in 113 …

A common feature of the malignant progression of human tumors is loss of heterozygosity
(LOH) for various regions of their genomes. Such events encompassing chromosomes …

Chromosome 17 is a frequent target during breast‐cancer formation and progression. It has
been shown to be affected by allele losses at multiple sites, as well as by DNA amplification …

Chromosome 17 is severely rearranged in breast cancer. Whereas the short arm undergoes
frequent losses, the long arm harbors complex combinations of gains and losses. In this …

Introduction One of the most common genetic aberrations associated with breast cancer is
the amplification and overexpression of the ERBB2 proto-oncogene located at chromosome …

In order to detect common regions of deletion, 219 breast tumors were examined for loss of
heterozygosity at several loci on chromosomes 3p, 16q, and 17 by restriction fragment …