Idiopathic pulmonary fibrosis (IPF) is a disease that causes scarring and fibrotic
transformation of the lung parenchyma, resulting in the progressive loss of respiratory …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease which leads to
significant morbidity and mortality from respiratory failure. The two drugs currently approved …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by alveolar
epithelial cell injury, accumulation of fibroblasts/myofibroblasts and deposition of …

Sphingolipids comprise a class of bioactive lipids that are involved in a variety of
pathophysiologic processes, including cell death and survival. Ceramide and sphingosine-1 …

Of the multiple and diverse homeostatic events that involve the lung vascular endothelium,
participation in preserving vascular integrity and therefore organ function is paramount. We …

Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle
them have been extensively investigated. Gas or inhaled particles or microorganisms come …

Sphingolipids form a broad class of lipids with diverse functions ranging from membrane
constituents to intracellular second messengers and extracellular mediators. They can be …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …

Cystic fibrosis (CF), one of the most common lethal hereditary diseases of white European
populations, is caused by loss-of-function mutations in the CF Transmembrane conductance …

Cystic Fibrosis (CF) lung disease is characterised by progressive chronic infection and
inflammation of the airways. This prolonged airway inflammatory response leads to …