Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S–C4b binding protein complex

SM Rezende, RE Simmonds, DA Lane - Blood, 2004 - ashpublications.org
Protein S (PS) has an established role as an important cofactor to activated protein C (APC)
in the degradation of coagulation cofactors Va and VIIIa. This anticoagulant role is evident …

The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells

L Kask, LA Trouw, B Dahlbäck, AM Blom - Journal of Biological Chemistry, 2004 - ASBMB
The phagocytosis of apoptotic cells is a complex process involving numerous interactions
between the target cell and the macrophage. We have examined a role of the major soluble …

Protein S: a conduit between anticoagulation and inflammation

AC Rigby, MA Grant - Critical care medicine, 2004 - journals.lww.com
Objective: To review the multifaceted roles of the anticoagulant protein S, facilitating a better
comprehension of this protein's role in anticoagulation and inflammation pathways and the …

[HTML][HTML] Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa.

TM Hackeng, C Van't Veer, JC Meijers… - Journal of Biological …, 1994 - Elsevier
Protein S is a vitamin K-dependent non-enzymatic coagulation factor involved in the
regulation of activated protein C (APC). In this paper we report an APC-independent …

[HTML][HTML] Anticoagulant protein S—New insights on interactions and functions

M Gierula, J Ahnström - Journal of Thrombosis and Haemostasis, 2020 - Elsevier
Protein S is a critical regulator of coagulation that functions as a cofactor for the activated
protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct …

Protein S as cofactor for TFPI

TM Hackeng, J Rosing - Arteriosclerosis, thrombosis, and vascular …, 2009 - Am Heart Assoc
In the last decades evidence was obtained that protein S not only acts as cofactor of
activated protein C (APC) in the downregulation of coagulation, but also expresses …

The tale of protein S and C4b-binding protein, a story of affection

B Dahlbäck - Thrombosis and haemostasis, 2007 - thieme-connect.com
F orThrombosis and Haemostasis' 50 th birthday I have been invited to write about a favorite
topic, focusing not only on thescientificaspectsbutalsoincludingsomehi… personal aspects. I …

The interaction of protein S with the phospholipid surface is essential for the activated protein C-independent activity of protein S

M van Wijnen, JG Stam, C van't Veer… - Thrombosis and …, 1996 - thieme-connect.com
Protein S is a vitamin-K dependent glycoprotein involved in the regulation of the
anticoagulant activity of activated protein C (APC). Recent data showed a direct …

Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells

JH Webb, AM Blom, B Dahlbäck - The Journal of Immunology, 2002 - journals.aai.org
Apoptosis is characterized by a lack of inflammatory reaction in surrounding tissues,
suggesting local control of complement activation. During the initial stage of apoptosis, cells …

Protein S and protein C: biochemistry, physiology, and clinical manifestation of deficiencies

CT Esmon - Trends in cardiovascular medicine, 1992 - Elsevier
Protein C and protein S are two plasma proteins that participate in an anticoagulant
pathway. Protein C circulates as an inactive precursor that is converted to an active serine …