Immunotherapy: building a bridge to a cure for type 1 diabetes

JA Bluestone, JH Buckner, KC Herold - Science, 2021 - science.org
Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the
insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase …

The immunology of type 1 diabetes

KC Herold, T Delong, AL Perdigoto, N Biru… - Nature Reviews …, 2024 - nature.com
Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

New frontiers in the treatment of type 1 diabetes

JT Warshauer, JA Bluestone, MS Anderson - Cell metabolism, 2020 - cell.com
Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

F Waldron-Lynch, KC Herold - Nature Reviews Drug Discovery, 2011 - nature.com
Type 1 diabetes is a common, severe chronic autoimmune disease that is characterized by
the progressive and insidious loss of self-tolerance to the insulin-producing pancreatic islet …

Current and future therapies for type 1 diabetes

BJ von Scholten, FF Kreiner, SCL Gough… - Diabetologia, 2021 - Springer
In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …

[HTML][HTML] Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials

TP Staeva, L Chatenoud, R Insel, MA Atkinson - Diabetes, 2013 - ncbi.nlm.nih.gov
Type 1 diabetes (T1D) results from the immune system's misguided attack on insulin-
producing pancreatic β-cells, leading to lifelong insulin replacement therapy as well as to …

Type 1 diabetes: etiology, immunology, and therapeutic strategies

TL Van Belle, KT Coppieters… - Physiological …, 2011 - journals.physiology.org
Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Type 1 diabetes: a chronic anti-self-inflammatory response

M Clark, CJ Kroger, RM Tisch - Frontiers in immunology, 2017 - frontiersin.org
Inflammation is typically induced in response to a microbial infection. The release of
proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as …

Targeting innate immune mediators in type 1 and type 2 diabetes

MY Donath, CA Dinarello… - Nature Reviews …, 2019 - nature.com
Type 1 and type 2 diabetes are characterized by chronic inflammation; both diseases
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …

Cytokines in type 1 diabetes: mechanisms of action and immunotherapeutic targets

J Lu, J Liu, L Li, Y Lan, Y Liang - Clinical & translational …, 2020 - Wiley Online Library
Cytokines play crucial roles in orchestrating complex multicellular interactions between
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …