The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …

The repair of myelin, termed remyelination, is a regenerative process that occurs within the
central nervous system in conditions such as multiple sclerosis. Remyelination is enabled by …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Objective: Failure of remyelination is a critical impediment to recovery in multiple sclerosis
(MS). Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS …

After inflammation-induced demyelination, such as in the disease multiple sclerosis,
endogenous remyelination often fails. However, in animal models of demyelination induced …

The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …

Background Chondroitin sulfate proteoglycan (CSPG) is a major component of the glial scar.
It is considered to be a major obstacle for central nervous system (CNS) recovery after injury …

Brain and spinal cord injury can result in permanent cognitive, motor, sensory and
autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for …

Chondroitin sulphate proteoglycans (CSPGs) are a family of inhibitory extracellular matrix
molecules that are highly expressed during development, where they are involved in …

Extracellular matrix (ECM) molecules in the central nervous system form highly organized
ECM structures around cell somata, axon initial segments, and synapses and play …