Longitudinal characterization of motor and cognitive deficits in a model of penetrating ballistic-like brain injury

DA Shear, XCM Lu, MC Bombard… - Journal of …, 2010 - liebertpub.com
Traumatic brain injury (TBI) produces a wide range of motor and cognitive changes. While
some neurological symptoms may respond to therapeutic intervention during the initial …

A bilateral head injury that shows graded brain damage and behavioral deficits in adultmice

NK Liu, YP Zhang, J O'Connor, A Gianaris, E Oakes… - Brain research, 2013 - Elsevier
Reliable animal models of traumatic brain injury (TBI) are essential to test novel hypotheses
and therapeutic interventions. In this study, based on advantages of both the closed head …

Sensorimotor behavioral tests for use in a juvenile rat model of traumatic brain injury: assessment of sex differences

KL Russell, KM Kutchko, SC Fowler… - Journal of neuroscience …, 2011 - Elsevier
Modeling juvenile traumatic brain injury (TBI) in rodents presents several unique challenges
compared to adult TBI, one of which is selecting appropriate sensorimotor behavioral tasks …

Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions

J Tsenter, L Beni-Adani, Y Assaf… - Journal of …, 2008 - liebertpub.com
Memory and neurobehavioral dysfunctions are among the sequelae of traumatic brain injury
(TBI). The Neurological Severity Score (NSS) includes 10 tasks and was previously …

[HTML][HTML] Early measures of TBI severity poorly predict later individual impairment in a rat fluid percussion model

SM Hetzer, A Casagrande, D Qu'd, N Dobrozsi… - Brain sciences, 2023 - mdpi.com
Background: Multiple measures of injury severity are suggested as common data elements
in preclinical traumatic brain injury (TBI) research. The robustness of these measures in …

Developing a cognition endpoint for traumatic brain injury clinical trials

ND Silverberg, PK Crane, K Dams-O'Connor… - Journal of …, 2017 - liebertpub.com
Cognitive impairment is a core clinical feature of traumatic brain injury (TBI). After TBI,
cognition is a key determinant of post-injury productivity, outcome, and quality of life. As a …

[HTML][HTML] Potential biomarkers in Experimental Animal models for traumatic brain Injury

UM Deshetty, P Periyasamy - Journal of clinical medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a complex and multifaceted disorder that has become a
significant public health concern worldwide due to its contribution to mortality and morbidity …

[HTML][HTML] Non-mammalian animal models offer new perspectives on the treatment of TBI

B Ganetzky, DA Wassarman - Current Physical Medicine and …, 2016 - Springer
Patients who have sustained a traumatic brain injury (TBI) exhibit clinical symptoms of
widely varying types and severities. In contrast, because of cost, experimental flexibility, and …

Greater neurobehavioral deficits occur in adult mice after repeated, as compared to single, mild traumatic brain injury (mTBI)

JN Nichols, AS Deshane, TL Niedzielko… - Behavioural brain …, 2016 - Elsevier
Mild traumatic brain injury (mTBI) accounts for the majority of all brain injuries and affected
individuals typically experience some extent of cognitive and/or neuropsychiatric deficits …

[HTML][HTML] Traumatic Brain Injury or Traumatic Brain Disease: A Scientific Commentary

AA OBASA, FE OLOPADE, SL JULIANO… - Brain Multiphysics, 2024 - Elsevier
ABSTRACT Traumatic Brain Injury (TBI) represents a major public health burden and a
major contributor to disability and death, especially in the young population. It remains one …