Deficits in discrimination after experimental frontal brain injury are mediated by motivation and can be improved by nicotinamide administration

C Vonder Haar, WR Maass, EA Jacobs… - Journal of …, 2014 - liebertpub.com
One of the largest challenges in experimental neurotrauma work is the development of
models relevant to the human condition. This includes both creating similar pathophysiology …

[HTML][HTML] Loss of consciousness and righting reflex following traumatic brain injury: predictors of post-injury symptom development (a narrative review)

R Berman, H Spencer, M Boese, S Kim, K Radford… - Brain sciences, 2023 - mdpi.com
Identifying predictors for individuals vulnerable to the adverse effects of traumatic brain
injury (TBI) remains an ongoing research pursuit. This is especially important for patients …

Weight-drop model as a valuable tool to study potential neurobiological processes underlying behavioral and cognitive changes secondary to mild traumatic brain …

CA Machado, B da Silva Oliveira, TL Dias… - Journal of …, 2023 - Elsevier
The pathophysiology of post-traumatic brain injury (TBI) behavioral and cognitive changes is
not fully understood, especially in its mild presentation. We designed a weight drop TBI …

A hierarchy of neurobehavioral tasks discriminates between mild and moderate brain injury in rats

SGA Baki, HY Kao, E Kelemen, AA Fenton, PJ Bergold - Brain research, 2009 - Elsevier
Behavioral analysis commonly assesses cognitive deficits in rodents following traumatic
brain injury (TBI). We examined rats that received sham, mild or moderate injury in the …

Minor functional deficits in basic response patterns for reinforcement after frontal traumatic brain injury in rats

C Vonder Haar, CA Winstanley - Journal of neurotrauma, 2016 - liebertpub.com
Traumatic brain injury (TBI) is a major contributor to numerous psychiatric conditions and
chronic behavioral dysfunction. Recent studies in experimental brain injury have begun to …

Evaluation of touchscreen chambers to assess cognition in adult mice: effect of training and mild traumatic brain injury

JN Nichols, KL Hagan, CL Floyd - Journal of Neurotrauma, 2017 - liebertpub.com
Cognitive impairments are often experienced after a mild traumatic brain injury (mTBI). In the
clinical arena, neuropsychological assessments are used frequently to detect cognitive …

Cognitive and neuropsychiatric impairments vary as a function of injury severity at 12 months post-experimental diffuse traumatic brain injury: Implications for dementia …

A Arulsamy, F Corrigan, LE Collins-Praino - Behavioural brain research, 2019 - Elsevier
Traumatic brain injury (TBI) is a common risk factor for later neurodegeneration, which can
manifest as dementia. Despite this, little is known about the time-course of development of …

[HTML][HTML] modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury

AD Sauerbeck, C Fanizzi, JH Kim, M Gangolli… - Scientific reports, 2018 - nature.com
Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI
models are a crucial component of therapeutic investigation. We report a tunable, monitored …

Visual dysfunction after repetitive mild traumatic brain injury in a mouse model and ramifications on behavioral metrics

NJ Morriss, GM Conley, N Hodgson… - Journal of …, 2021 - liebertpub.com
Mild traumatic brain injury (mTBI) is a major cause of morbidity and mortality with a poorly
understood pathophysiology. Animal models have been increasingly utilized to better …

[HTML][HTML] Translational considerations for behavioral impairment and rehabilitation strategies after diffuse traumatic brain injury

TC Thomas, TA Colburn, K Korp, A Khodadad… - 2015 - europepmc.org
Millions of diffuse traumatic brain injuries (TBI) occur annually through sports-related
incidents, motor vehicle accidents, falls and violence; many of which are never reported …