Advancing therapy for osteosarcoma

J Gill, R Gorlick - Nature reviews Clinical oncology, 2021 - nature.com
Improving the survival of patients with osteosarcoma has long proved challenging, although
the treatment of this disease is on the precipice of advancement. The increasing feasibility of …

Osteosarcoma: current treatment and a collaborative pathway to success

MS Isakoff, SS Bielack, P Meltzer… - Journal of clinical …, 2015 - ascopubs.org
Osteosarcoma is the bone tumor that most commonly affects children, adolescents, and
young adults. Before 1970, treatment primarily included surgical resection. However, the …

Current and future therapeutic approaches for osteosarcoma

DJ Harrison, DS Geller, JD Gill, VO Lewis… - Expert review of …, 2018 - Taylor & Francis
Introduction: Current treatment of osteosarcoma includes surgical resection of all gross
disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This …

Osteosarcoma: accelerating progress makes for a hopeful future

AJ Saraf, JM Fenger, RD Roberts - Frontiers in oncology, 2018 - frontiersin.org
Patients who develop osteosarcoma in 2017 receive treatment that remains essentially
unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large …

The current and future therapies for human osteosarcoma

JD Lamplot, S Denduluri, J Qin, R Li… - Current cancer …, 2013 - ingentaconnect.com
Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in adults
and children. As sarcomas are more common in adolescents and young adults than most …

Osteosarcoma pathogenesis leads the way to new target treatments

I Fernandes, C Melo-Alvim, R Lopes-Brás… - International journal of …, 2021 - mdpi.com
Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic
research has enabled a better understanding of OS pathogenesis and the discovery of new …

Targeted therapy for osteosarcoma: a review

S Li, H Zhang, J Liu, G Shang - Journal of cancer research and clinical …, 2023 - Springer
Background Osteosarcoma is a common primary malignant tumour of the bone that usually
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …

Osteosarcoma treatment: state of the art

HT Ta, CR Dass, PFM Choong, DE Dunstan - Cancer and Metastasis …, 2009 - Springer
Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or
young adults. It is the second highest cause of cancer-related death in these age groups …

Advances in emerging drugs for osteosarcoma

CM Hattinger, M Fanelli, E Tavanti, S Vella… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Osteosarcoma (OS), the most common primary malignant bone tumor, is
currently treated with pre-and postoperative chemotherapy in association with the surgical …

The molecular pathogenesis of osteosarcoma: a review

ML Broadhead, JCM Clark, DE Myers, CR Dass… - Sarcoma, 2011 - Wiley Online Library
Osteosarcoma is the most common primary malignancy of bone. It arises in bone during
periods of rapid growth and primarily affects adolescents and young adults. The 5‐year …