Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …

Background: Naphthoquinones are a class of aromatic compounds relevant for their
chemical characteristics, structural properties, and biological activity. These compounds are …

In the search for new therapeutic alternatives for Chagas disease, a series of six aryloxy-
naphthoquinone derivatives were synthesized and evaluated in vitro against Trypanosoma …

This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone,
examples of bioactive natural products that still being under biological evaluation and …

In continuation our effort to research the chemical space of aryloxy-naphthoquinones as
potential anti-Chagas agents, we synthesized nine derivatives and these compounds were …

A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1, 4-
naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their …

Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids
Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered …

Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …