Naphthoquinones are secondary plant metabolites that are used to treat a variety of human
ailments in traditional medicine. In light of this, the synthesis of derivatives of …

Current chemotherapy drugs for Chagas' disease are insufficient due to their limited efficacy;
however, anti-trypanosomal agents have recently shown promise. As such, synthetic …

This study reports on the design, synthesis and antiparasitic activity of three new semi-
synthetic naphthoquinones structurally related to the naturally-occurring lapachol and …

Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and
Verbenaceae have been subject of a programme on the chemistry of natural products active …

Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects
approximately 6–7 million people worldwide. Benznidazole is the only drug approved for …

Malaria is a major tropical disease, which kills two million people annually. The population
at risk from this disease has increased because of the difficulties in eradicating the mosquito …

The biological activities of the naphthoquinones lapachol and its cyclization product β-
lapachone, extracted from trees of the genus Tabebuia, have been intensively studied …

Chagas disease represents one of several neglected diseases with a reduced number of
chemotherapeutical drugs including the highly toxic compounds benznidazole and …

Two series of diaryl-tetrahydrofuran and-furan were synthesised and screened for anti-
trypanosomal activity against trypomastigote and amastigote forms of Trypanosoma cruzi …

An antikinetoplastid pharmacomodulation study was conducted at position 6 of the 8-
nitroquinolin-2 (1 H)-one pharmacophore. Fifteen new derivatives were synthesized and …