ONYX-015 has been reported to kill selectively tumor cells lacking functional p53. Genetic
alterations of INK4a/ARF locus, which is a predominant event in malignant pleural …

Abstract p53 mutations and loss of heterozygosity (LOH) have been detected in> 50% of
lung cancers. Wild-type p53 can prevent replication of damaged DNA and promote …

Malignant pleural mesotheliomas (MPMs) are usually wild type for the p53 gene but contain
homozygous deletions in the INK4A locus that encodes p14 ARF, an inhibitor of p53-MDM2 …

Abstract ONYX-015, dl1520, is an adenovirus that lacks the E1B 55K gene and therefore
lacks the capacity to neutralize p53 during infection. This virus induces high levels of p53 …

The ONYX-015 virus is a mutated adenovirus that in theory selectively replicates and
induces cytolysis in tumor cells lacking functional p53. The present study investigated …

Background: Though p53 mutations are rare in ES, there is a strong indication that p53
mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies …

dl1520 (ONYX-015) is an adenovirus mutant that lacks the E1b 55K gene. As a result it
cannot neutralize p53. Therefore dl1520 should only grow in cells that lack p53, and should …

The tumor suppressor protein, p53, plays a critical role in viro-oncology. However, the role of
p53 in adenoviral replication is still poorly understood. In this paper, we have explored …

p14ARF, the alternative product from the human INK4a/ARF locus, is one of the major
targets for alterations in the development of human cancers. Overexpression of p14ARF …

The majority of malignant mesothelioma possesses the wild-type p53 gene with a
homologous deletion of the INK4A/ARF locus containing the p14 ARF and the p16 INK4A …