Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

Glucocorticoid insensitivity presents a profound management problem in patients with
asthma because conventional therapies are not effective. Glucocorticoids, acting through the …

Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Glucocorticoids are the mainstay of asthma management and effectively treat acute
exacerbations of asthma. However, a small subset of asthmatics, usually with severe …

Synthetic glucocorticoids are the most potent anti‐inflammatory agents used to treat chronic
inflammatory disease, such as asthma. However, a small number (< 5%) of asthmatic …

Glucocorticoids are potent inhibitors of inflammatory processes and are widely used in the
treatment of asthma. The anti‐inflammatory effects are mediated either by direct binding of …

Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases
including asthma and chronic obstructive pulmonary disease (COPD). However, it has been …

Glucocorticoids are highly effective in the control of asthma and other chronic inflammatory
or immune diseases. The value of steroids in asthma became apparent soon after the …

The disproportionate cost of treating asthmatic patients who do not respond to conventional
anti-inflammatory therapies makes delineation of the mechanism for glucocorticoid …