The vanilloid type 1 ion channel (TRPV1) is known to play an important role in the regulation
of pain and inflammation. Pharmacological ligands of TRPV1 regulate human osteoclast …

Background and Purpose Osteoporosis is a condition characterized by a decrease in bone
density, which decreases its strength and results in fragile bones. The endocannabinoid …

Capsaicin, a transient receptor potential vanilloid type 1 (TRPV1) ligand, regulates nerve‐
related pain‐sensitive signals, inflammation, and cancer growth. Capsaicin suppresses …

The inhibitor effect of estrogen on osteoclasts differentiation is very important in the etiology
of estrogen protecting the adult skeleton against bone loss. However, the precise molecular …

Osteoclast differentiation is critically dependent on calcium (Ca2+) signaling. Transient
receptor potential vanilloid 4 (TRPV4), mediates Ca2+ influx in the late stage of osteoclast …

Objective Mechanical loading significantly influences the physiology and pathology of
articular cartilage, although the mechanisms of mechanical signal transduction are not fully …

Bisphosphonates (BPs) reduce bone pain and fractures by balancing the
osteoblast/osteoclast ratio. The behavior of ion channels in the presence of BPs is not …

Objectives Calcium ion signals are important for osteoclast differentiation. Transient receptor
potential vanilloid 6 (TRPV6) is a regulator of bone homeostasis. However, it was unclear …

We explored the role of transient receptor potential vanilloid 4 (TRPV4) in murine bone
metabolism and association of TRPV4 gene variants with fractures in humans. Urinary and …

Background: Calcium ion (Ca 2+) signals are required for osteoclast differentiation. Previous
study showed that transient receptor potential vanilloid 5 (TRPV5) is an essential Ca 2+ …