Gold (III) complexes in the oncological preclinical arena: from aminoderivatives to peptidomimetics

C Nardon, D Fregona - Current topics in medicinal chemistry, 2016 - ingentaconnect.com
In the last decade, we have been developing some gold (III) derivatives showing interesting
antitumor properties and reduced systemic and renal toxicity, compared to the clinically …

Gold (I) complexes with thiosemicarbazones: cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity

JA Lessa, JC Guerra, LF de Miranda… - Journal of inorganic …, 2011 - Elsevier
Complexes [Au (H2Ac4DH) Cl]∙ MeOH (1)[Au (H22Ac4Me) Cl] Cl (2)[Au (H22Ac4Ph) Cl] Cl∙
2H2O (3) and [Au (H22Bz4Ph) Cl] Cl (4) were obtained with 2-acetylpyridine …

Naphthalimide gold (I) phosphine complexes as anticancer metallodrugs

CP Bagowski, Y You, H Scheffler, DH Vlecken… - Dalton …, 2009 - pubs.rsc.org
Gold (I) phosphine complexes exhibit promising properties for anticancer drug development.
Here we report on a series of gold (I) phosphine complexes containing a naphthalimide …

The electrochemical profiles of Auranofin and Aubipyc, two representative medicinal gold compounds: A comparative study

M Kupiec, R Ziółkowski, L Massai, L Messori… - Journal of Inorganic …, 2019 - Elsevier
A micro-electrochemical reaction cell was coupled to an electrospray mass spectrometer in
order to track redox transformations for two representative medicinal gold compounds-ie [(2 …

Breast Cancer Treatment: The Case of Gold (I)-Based Compounds as a Promising Class of Bioactive Molecules

R Galassi, L Luciani, J Wang, S Vincenzetti, L Cui… - Biomolecules, 2022 - mdpi.com
Breast cancers (BCs) may present dramatic diagnoses, both for ineffective therapies and for
the limited outcomes in terms of lifespan. For these types of tumors, the search for new drugs …

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

B Bertrand, A Casini - Dalton Transactions, 2014 - pubs.rsc.org
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …

Advances in diphosphine ligand-containing gold complexes as anticancer agents

N Mirzadeh, TS Reddy, SK Bhargava - Coordination Chemistry Reviews, 2019 - Elsevier
The last decade has witnessed tremendous advances in the design of anticancer gold
complexes containing tertiary phosphines, a class of ligands that have significantly …

Gold metalation of proteins: Structural studies

A Giorgio, A Merlino - Coordination Chemistry Reviews, 2020 - Elsevier
Gold compounds have emerged as a novel class of metallodrugs with a promising future in
medicinal inorganic chemistry. Despite gold compounds have been intensively investigated …

Synthesis, characterization and biological activity of bromido [3-ethyl-4-aryl-5-(2-methoxypyridin-5-yl)-1-propyl-1, 3-dihydro-2 H-imidazol-2-ylidene] gold (i) complexes

CM Gallati, SK Goetzfried, M Ausserer… - Dalton …, 2020 - pubs.rsc.org
Bromido [3-ethyl-4-aryl-5-(2-methoxypyridin-5-yl)-1-propyl-1, 3-dihydro-2H-imidazol-2-
ylidene] gold (I) complexes (8a–h) with methoxy, methyl and fluorine substituents at different …

Cytotoxic Gold (I) N‐heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors

R Rubbiani, L Salassa, A De Almeida… - …, 2014 - Wiley Online Library
Organometallic gold complexes with N‐heterocyclic carbene (NHC) ligands have been
demonstrating promising properties as novel anticancer agents. Gold (I) NHC complexes …