In Caenorhabditis elegans, the insulin/IGF-1 DAF-2 receptor controls entry into dauer and
longevity. DAF-2 signaling cascade includes the PI3 kinase homolog AGE-1 and the FOXO …

In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced
insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different …

Previous studies have revealed the importance of inter-tissue communications for lifespan
regulation. However, the inter-tissue network responsible for lifespan regulation is not well …

The forkhead transcription factor, DAF-16, a downstream target of the insulin/IGF-I signaling
pathway in C. elegans, is indispensable both for lifespan regulation and stress resistance …

Background Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C.
elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of …

Mutations in daf-2 and age-1 cause a dramatic increase in longevity as well as
developmental arrest at the dauer diapause stage in Caenorhabditis elegans. daf-2 and age …

Summary The DAF‐2 insulin/insulin‐like growth factor 1 (IGF‐1) receptor signals via a
phosphatidylinositol 3‐kinase (PI3K) pathway to control dauer larva formation and adult …

The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor
(IGF)-1 receptor homolog DAF-2, which signals through a conserved phosphatidylinositol 3 …

Background Previous genetic evidence suggested that the C. elegans TGF-β Dauer
pathway is responsible solely for the regulation of dauer formation, with no role in longevity …

Aging: New Targets, New Functions: Current Biology Skip to Main Content Advertisement
Current Biology This journal offers authors two options (open access or subscription) to publish …